ING-2 AM

Name: ING-2 AM | Sodium Indicator | ION Biosciences
SKU: 2011
Availability: InStock

Price range: $181.00 through $410.00

ING-2 AM is a yellow-green fluorescent, sodium indicator. Membrane-permeable. Higher sodium affinity than ING-1. Suitable for high throughput screening of sodium channels and transporters.

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Variation	SKU	Price	Quantity	Action
Size: 3 x 50 ug	2011G	$181.00	ING-2 AM quantity	Add to cart
Size: 10 x 50 ug	2011F	$410.00	ING-2 AM quantity	Add to cart
Size: 500 ug	2011C	$410.00	ING-2 AM quantity	Add to cart

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Packaging for ING-2 AM, a fluorescent sodium indicator

ING-2 AM (Ion natrium green - 2) packaging with sodium (Na+) ion sticker, transparent background

ING-2 (Ion natrium green - 2), a sodium indicator, excitation and emission spectra

SKU: 2011 Categories: Ion indicators, Sodium Synonyms: Asante Natrium Green - 2 (ANG-2), ing, ing 2, ION Natrium Green - 2, sodium, variable

Specifications

Excitation: 525 nm

Emission: 545 nm

Kd: 20 mM

MW: 1084 g/mol

Solubility: DMSO

Purity: >90%

Filter Set: GFP, FITC, YFP

Storage: -20°C

Size: 10 x 50 ug, 3 x 50 ug, 500 ug

Product Description

ION Natrium Green – 2 (ING-2) is a yellow-green fluorescent, intracellular sodium (Na⁺) indicator with improved cellular loading and significantly higher brightness than SBFI. Its spectral properties (Ex/Em: 525 nm/545 nm) and large dynamic range make ING-2 the best Na⁺ indicator for high-throughput screening applications targeting Na⁺ channels, and non-selective monovalent cation channels. ING-2 has a more physiologically relevant affinity (Kd = 20 mM) than ING-1 (Kd = 92 mM). Also compatible with fluorescence microscopy using common fluorescein, GFP or more ideally YFP filters.

Fluorescence emission data of ING-2 binding to sodium ion (Na+) at different concentrations, and a sodium binding curve.

Dose response curve and fluorescence images of ouabain treated cells loaded with ING-2. Ouabain inhibits the sodium potassium pump (Na/K-ATPase).

Ouabain concentration response curve acquired using ING-2 AM, showing inhibition of the sodium-potassium pump (Na/K-ATPase).

Plotted change in fluorescence of ING-2 in response to sodium concentration

Measuring sodium channel activity using the sodium indicator, ING-2 AM. Inactivation of Nav1.3, a voltage gated sodium channel, is blocked by veratridine, resulting in an increase in cellular fluorescence.

Documentation

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